Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis.

ABSTRACT:

Background

IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.

Objective

to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.

Methods

Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to investigate the alterations in plasma proteomic profiles. For the bioinformatics analyses, databases including Uniprot, PANTHER, KEGG, Reactome, Cytoscape, and IntAct were used.

Results

Among the 418 prote

SUBMITTER: Demir S 

PROVIDER: S-EPMC10217085 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature