Dataset Information

Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook.

ABSTRACT: (1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, Central, and the Web of Science using the query "pet ligands" and "tauopathies". Articles published from January 2018 to 9 February, 2023, were searched. Only studies on the development of novel PET radiotracers for imaging in tauopathies or comparative studies between existing PET tracers were included. (3) Results: A total of 126 articles were found, as follows: 96 were identified from PubMed, 27 from Scopus, one on Central, two on Medline, and zero on the Web of Science. Twenty-four duplicated works were excluded, and 63 articles did not satisfy the inclusion criteria. The remaining 40 articles were included for quality assessment. (4) Conclusions: PET imaging represents a valid instrument capable of helping clinicians in diagnosis, but it is not always perfect in differential diagnosis, even if further investigations on humans for novel promising ligands are needed.

SUBMITTER: Conte M

PROVIDER: S-EPMC10217406 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook.

Conte Miriam M De Feo Maria Silvia MS Sidrak Marko Magdi Abdou MMA Corica Ferdinando F Gorica Joana J Granese Giorgia Maria GM Filippi Luca L De Vincentis Giuseppe G Frantellizzi Viviana V

Diagnostics (Basel, Switzerland) 20230509 10

(1) Background: Tauopathies are a group of diseases characterized by the deposition of abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also include Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Positron emission tomography (PET) imaging represents a pivotal instrument to guide clinicians. This systematic review aims to summarize the current and novel PET tracers. (2) Methods: Literature research was conducted on Pubmed, Scopus, Medline, ...[more]

PMID: 37238166

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Dataset Information

Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook.

Publications

Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook.

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