Putative Wound Healing Induction Functions of Exosomes Isolated from IMMUNEPOTENT CRP.

ABSTRACT: Chronic wounds in diabetic patients can take months or years to heal, representing a great cost for the healthcare sector and impacts on patients' lifestyles. Therefore, new effective treatment alternatives are needed to accelerate the healing process. Exosomes are nanovesicles involved in the modulation of signaling pathways that can be produced by any cell and can exert functions similar to the cell of origin. For this reason, IMMUNEPOTENT CRP, which is a bovine spleen leukocyte extract, was analyzed to identify the proteins present and is proposed as a source of exosomes. The exosomes were isolated through ultracentrifugation and shape-size, characterized by atomic force microscopy. The protein content in IMMUNEPOTENT CRP was characterized by EV-trap coupled to liquid chromatography. Th

SUBMITTER: Garcia Coronado PL 

PROVIDER: S-EPMC10218804 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature