Unknown

Dataset Information

0

The Mutational Landscape of SARS-CoV-2.


ABSTRACT: Mutation research is crucial for detecting and treating SARS-CoV-2 and developing vaccines. Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python programs, we analyzed the mutational landscape of SARS-CoV-2. Although almost every nucleotide in the SARS-CoV-2 genome has mutated at some time, the substantial differences in the frequency and regularity of mutations warrant further examination. C>U mutations are the most common. They are found in the largest number of variants, pangolin lineages, and countries, which indicates that they are a driving force behind the evolution of SARS-CoV-2. Not all SARS-CoV-2 genes have mutated in the same way. Fewer non-synonymous single nucleotide variations are found in genes that encode proteins with a critical role in virus replication than in genes with ancillary roles. Some genes, such as spike (S) and nucleocapsid (N), show more non-synonymous mutations than others. Although the prevalence of mutations in the target regions of COVID-19 diagnostic RT-qPCR tests is generally low, in some cases, such as for some primers that bind to the N gene, it is significant. Therefore, ongoing monitoring of SARS-CoV-2 mutations is crucial. The SARS-CoV-2 Mutation Portal provides access to a database of SARS-CoV-2 mutations.

SUBMITTER: Saldivar-Espinoza B 

PROVIDER: S-EPMC10219494 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

altmetric image

Publications


Mutation research is crucial for detecting and treating SARS-CoV-2 and developing vaccines. Using over 5,300,000 sequences from SARS-CoV-2 genomes and custom Python programs, we analyzed the mutational landscape of SARS-CoV-2. Although almost every nucleotide in the SARS-CoV-2 genome has mutated at some time, the substantial differences in the frequency and regularity of mutations warrant further examination. C>U mutations are the most common. They are found in the largest number of variants, pa  ...[more]

Similar Datasets

| S-EPMC8669838 | biostudies-literature
| S-EPMC8830725 | biostudies-literature
| S-EPMC8784435 | biostudies-literature
| S-EPMC9300961 | biostudies-literature
| S-EPMC9779650 | biostudies-literature
| S-EPMC8648120 | biostudies-literature
| S-EPMC8913432 | biostudies-literature
| S-EPMC9802038 | biostudies-literature
| S-EPMC8492600 | biostudies-literature
| S-EPMC9015223 | biostudies-literature