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In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2.

ABSTRACT: The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (Larrea tridentata) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the SARS-CoV-2 cytopathic effect, viral plaque formation, RNA replication, and expression of the SARS-CoV-2 spike glycoprotein. The 50% effective concentration for NDGA was as low as 16.97 µM. Our results show that NDGA could be a promising therapeutic candidate against SARS-CoV-2.

SUBMITTER: Villalobos-Sanchez E

PROVIDER: S-EPMC10222355 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2.

Villalobos-Sánchez Erendira E García-Ruiz Daniel D Camacho-Villegas Tanya A TA Canales-Aguirre Alejandro A AA Gutiérrez-Ortega Abel A Muñoz-Medina José E JE Elizondo-Quiroga Darwin E DE

Viruses 20230511 5

The coronavirus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been spreading rapidly worldwide, creating a pandemic. This article describes the evaluation of the antiviral activity of nordihydroguaiaretic acid (NDGA), a molecule found in Creosote bush (<i>Larrea tridentata</i>) leaves, against SARS-CoV-2 in vitro. A 35 µM concentration of NDGA was not toxic to Vero cells and exhibited a remarkable inhibitory effect on the ...[more]

PMID: 37243241

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