Dilated Virchow-Robin spaces are a marker for arterial disease in multiple sclerosis.

ABSTRACT:

Background

Virchow-Robin spaces (VRS) have been associated with neurodegeneration and neuroinflammation. However, it remains uncertain to what degree non-dilated or dilated VRS reflect specific features of neuroinflammatory pathology. Thus, we aimed at investigating the clinical relevance of VRS as imaging biomarker in multiple sclerosis (MS) and to correlate VRS to their histopathologic signature.

Methods

In a cohort study comprising 142 MS patients and 30 control subjects, we assessed the association of non-dilated and dilated VRS to clinical and magnetic resonance imaging (MRI) outcomes. Findings were corroborated in a validation cohort comprising 63 MS patients. Brain blocks from 6 MS patients and 3 non-MS controls were histopathologically processed to correlate VRS to t

SUBMITTER: Ineichen BV 

PROVIDER: S-EPMC10227207 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature