Dataset Information

Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City.

ABSTRACT:

Background

The SARS-CoV-2 virus has caused unprecedented mortality since its emergence in late 2019. The continuous evolution of the viral genome through the concerted action of mutational forces has produced distinct variants that became dominant, challenging human immunity and vaccine development.

Aim and methods

In this work, through an integrative genomic approach, we describe the molecular transition of SARS-CoV-2 by analyzing the viral whole genome sequences from 50 critical COVID-19 patients recruited during the first year of the pandemic in Mexico City.

Results

Our results revealed differential levels of the evolutionary forces across the genome and specific mutational processes that have shaped the first two epidemiological waves of the pandemic in Mexico. Through phylogenetic analyses, we observed a genomic transition in the circulating SARS-CoV-2 genomes from several lineages prevalent in the first wave to a dominance of the B.1.1.519 variant (defined by T478K, P681H, and T732A mutations in the spike protein) in the second wave.

Conclusion

This work contributes to a better understanding of the evolutionary dynamics and selective pressures that act at the genomic level, the prediction of more accurate variants of clinical significance, and a better comprehension of the molecular mechanisms driving the evolution of SARS-CoV-2 to improve vaccine and drug development.

SUBMITTER: De La Cruz-Montoya AH

PROVIDER: S-EPMC10227454 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City.

De La Cruz-Montoya Aldo Hugo AH Díaz Velásquez Clara Estela CE Martínez-Gregorio Héctor H Ruiz-De La Cruz Miguel M Bustos-Arriaga José J Castro-Jiménez Tannya Karen TK Olguín-Hernández Jonadab Efraín JE Rodríguez-Sosa Miriam M Terrazas-Valdes Luis Ignacio LI Jiménez-Alvarez Luis Armando LA Regino-Zamarripa Nora Elemi NE Ramírez-Martínez Gustavo G Cruz-Lagunas Alfredo A Peralta-Arrieta Irlanda I Armas-López Leonel L Contreras-Garza Belinda Maricela BM Palma-Cortés Gabriel G Cabello-Gutierrez Carlos C Báez-Saldaña Renata R Zúñiga Joaquín J Ávila-Moreno Federico F Vaca-Paniagua Felipe F

Frontiers in cellular and infection microbiology 20230516

<h4>Background</h4>The SARS-CoV-2 virus has caused unprecedented mortality since its emergence in late 2019. The continuous evolution of the viral genome through the concerted action of mutational forces has produced distinct variants that became dominant, challenging human immunity and vaccine development.<h4>Aim and methods</h4>In this work, through an integrative genomic approach, we describe the molecular transition of SARS-CoV-2 by analyzing the viral whole genome sequences from 50 critical ...[more]

PMID: 37260697

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Dataset Information

Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City.

Background

Aim and methods

Results

Conclusion

Publications

Molecular transition of SARS-CoV-2 from critical patients during the first year of the COVID-19 pandemic in Mexico City.

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