Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans.

ABSTRACT: The causality and mechanism of dietary effects on brain aging are still unclear due to the long time scales of aging. The nematode Caenorhabditis elegans has contributed to aging research because of its short lifespan and easy genetic manipulation. When fed the standard laboratory diet, Escherichia coli, C. elegans experiences an age-dependent decline in temperature-food associative learning, called thermotaxis. To address if diet affects this decline, we screened 35 lactic acid bacteria as alternative diet and found that animals maintained high thermotaxis ability when fed a clade of Lactobacilli enriched with heterofermentative bacteria. Among them, Lactobacillus reuteri maintained the thermotaxis of aged animals without affecting their lifespan

SUBMITTER: Higurashi S 

PROVIDER: S-EPMC10229132 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature