Predicting the Abscopal Effect: Associated Tumor Histologic Subtypes and Biomarkers.

ABSTRACT: Radiotherapy is a pillar of cancer treatment, which has historically been used primarily to treat localized disease with curative intent. With the increasing role of radiotherapy for metastatic disease and rapid integration of immunotherapy into the standard of care for various cancers, it has been observed that local radiation to one malignant site can lead to shrinkage of tumors at other sites, a phenomenon termed the "abscopal effect." Historically, there was little mechanistic elucidation as to how this phenomenon occurs. However, multiple groups have recently identified associated immuno-prognostic factors, such as high post-radiotherapy absolute lymphocyte count, neoantigens, myeloid-derived suppressor cells, and NK cells. The concomitant use of immunotherapy with radiotherapy has be

SUBMITTER: Nelson BE 

PROVIDER: S-EPMC10233357 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature