Glycyl-l-histidyl-l-lysine-Cu²⁺ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.

ABSTRACT:

Background

Skeletal muscle dysfunction is an important co-morbidity in patients with chronic obstructive pulmonary disease (COPD) and is significantly associated with increased mortality. Oxidative stress has been demonstrated an important trigger for COPD-related skeletal muscle dysfunction. Glycine-histidine-lysine (GHK) is an active tripeptide, which is a normal component of human plasma, saliva, and urine; promotes tissue regeneration; and acts as an anti-inflammatory and antioxidant properties. The purpose of this study was to determine whether GHK is involved in COPD-related skeletal muscle dysfunction.

Methods

The plasma GHK level in patients with COPD (n = 9) and age-paired healthy subjects (n = 11) were detected using reversed-phase high-performance liquid chromatog

SUBMITTER: Deng M 

PROVIDER: S-EPMC10235902 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature