Low prevalence of mobilized resistance genes bla_NDM, mcr-1, and tet(X4) in Escherichia coli from a hospital in China.

ABSTRACT: The emergence and spread of carbapenemase genes, colistin resistance genes mcr-1, and tigecycline resistance gene tet(X) represent a significant threat to clinical therapy and public health. In this study, we investigated the presence of carbapenemase genes, mcr-1, and tet(X) in 298 Escherichia coli strains obtained from a teaching hospital in China. In total, eight (2.68%), six (2.01%), and one (0.34%) E. coli isolates carried bla_NDM, mcr-1, and tet(X4), respectively. The bla_NDM gene was located on IncX3 (n = 4), F2:A-:B- (n = 3), and F2:A1:B1 (n = 1) plasmids, with high similarity to multiple plasmids belonging to the same incompatibility type from Enterobacteriaceae. Six MCR-

SUBMITTER: Sun L 

PROVIDER: S-EPMC10237293 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature