Low-polarity untargeted metabolomic profiling as a tool to gain insight into seminal fluid.

ABSTRACT:

Introduction

A decrease in sperm cell count has been observed along the last several decades, especially in the most developed regions of the world. The use of metabolomics to study the composition of the seminal fluid is a promising approach to gain access to the molecular mechanisms underlying this fact.

Objectives

In the present work, we aimed at relating metabolomic profiles of young healthy men to their semen quality parameters obtained from conventional microscopic analysis.

Methods

An untargeted metabolomics approach focusing on low- to mid-polarity compounds was used to analyze a subset of seminal fluid samples from a cohort of over 2700 young healthy men.

Results

Our results show that a broad metabolic profiling comprising several families of compounds

SUBMITTER: Olesti E 

PROVIDER: S-EPMC10239740 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature