The Association of Alcohol Consumption with Glaucoma and Related Traits: Findings from the UK Biobank.

ABSTRACT:

Purpose

To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition to glaucoma modified these associations, and to perform Mendelian randomization (MR) experiments to probe causal effects.

Design

Cross-sectional observational and gene-environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia.

Participants

UK Biobank participants with data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness measures (n = 46 236) and glaucoma status (n = 173 407).

Methods

Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were deri

SUBMITTER: Stuart KV 

PROVIDER: S-EPMC10239785 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature