Role of small airway dysfunction in unexplained exertional dyspnoea.

ABSTRACT:

Background

Isolated small airway abnormalities may be demonstrable at rest in patients with normal spirometry; however, the relationship of these abnormalities to exertional symptoms remains uncertain. This study uses an augmented cardiopulmonary exercise test (CPET) to include evaluation of small airway function during and following exercise to unmask abnormalities not evident with standard testing in individuals with dyspnoea and normal spirometry.

Methods

Three groups of subjects were studied: 1) World Trade Center (WTC) dust exposure (n=20); 2) Clinical Referral (n=15); and Control (n=13). Baseline evaluation included respiratory oscillometry. Airway function during an incremental workload CPET was assessed by: 1) tidal flow versus volume curves during exercise to

SUBMITTER: Sharpe AL 

PROVIDER: S-EPMC10240305 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature