Dual targeting PET tracer [⁶⁸Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study.

ABSTRACT: Rationale: Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment. PET/CT has become increasingly recognized as a valuable imaging modality for these patients, but there remains room for improvement in PET tracers. We aimed to evaluate the feasibility of using [⁶⁸Ga]Ga-FAPI-RGD, a dual-targeting heterodimeric PET tracer that recognizes both fibroblast activation protein (FAP) and integrin α_vβ₃ for detecting lung neoplasms, by comparing it with [¹⁸F]FDG and single-targeting tracers [⁶⁸Ga]Ga-RGD and [⁶⁸Ga]Ga-FAPI. Methods: This was a pilot exploratory study of patients with suspected lung malignancies. All 51 participants underwent [⁶⁸

SUBMITTER: Wang R 

PROVIDER: S-EPMC10240811 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature