Highly Selective Radical Relay 1,4-Oxyimination of Two Electronically Differentiated Olefins.

ABSTRACT: Radical addition reactions of olefins have emerged as an attractive tool for the rapid assembly of complex structures, and have plentiful applications in organic synthesis, however, such reactions are often limited to polymerization or 1,2-difunctionalization. Herein, we disclose an unprecedented radical relay 1,4-oxyimination of two electronically differentiated olefins with a class of bifunctional oxime carbonate reagents via an energy transfer strategy. The protocol is highly chemo- and regioselective, and three different chemical bonds (C-O, C-C, and C-N bonds) were formed in a single operation in an orchestrated manner. Notably, this reaction provides rapid access to a large variety of structurally diverse 1,4-oxyimination products, and the obtained products could be easily converted

SUBMITTER: Tan G 

PROVIDER: S-EPMC10242452 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature