Increased METTL3 expression and m⁶A RNA methylation may contribute to the development of dry eye in primary Sjogren's syndrome.

ABSTRACT:

Background

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder defined by xerostomia and keratoconjunctivitis sicca, and its etiology remains unknown. N6-methyladenosine (m⁶A) is the predominant posttranscriptional modification in eukaryotic mRNAs and is dynamically regulated by m⁶A regulators. Dysregulation of m⁶A modification is closely associated with several autoimmune disorders, but the role of m⁶A modification in pSS remains unknown. This study investigated the potential role of m⁶A and m⁶A-related regulators in pSS patients with dry eye.

Methods

This cross-sectional study included forty-eight pSS patients with dry eye and forty healthy controls (HCs). Peripheral blood mononuclear cells (PB

SUBMITTER: Ma J 

PROVIDER: S-EPMC10243060 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature