IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis.

ABSTRACT:

Background

Epithelial remodeling is a histopathologic feature of chronic inflammatory airway diseases including chronic rhinosinusitis (CRS). Cell-type shifts and their relationship to CRS endotypes and severity are incompletely described.

Objective

We sought to understand the relationship of epithelial cell remodeling to inflammatory endotypes and disease outcomes in CRS.

Methods

Using cell-type transcriptional signatures derived from epithelial single-cell sequencing, we analyzed bulk RNA-sequencing data from sinus epithelial brushings obtained from patients with CRS with and without nasal polyps in comparison to healthy controls.

Results

The airway epithelium in nasal polyposis displayed increased tuft cell transcripts and decreased ciliated cell transcripts

SUBMITTER: Kotas ME 

PROVIDER: S-EPMC10243183 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature