Psychopathology in adults with copy number variants.

ABSTRACT:

Background

Copy number variants (CNVs) have been associated with the risk of schizophrenia, autism and intellectual disability. However, little is known about their spectrum of psychopathology in adulthood.

Methods

We investigated the psychiatric phenotypes of adult CNV carriers and compared probands, who were ascertained through clinical genetics services, with carriers who were not. One hundred twenty-four adult participants (age 18-76), each bearing one of 15 rare CNVs, were recruited through a variety of sources including clinical genetics services, charities for carriers of genetic variants, and online advertising. A battery of psychiatric assessments was used to determine psychopathology.

Results

The frequencies of psychopathology were consistently higher for th

SUBMITTER: Adams RL 

PROVIDER: S-EPMC10244007 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature