Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks.

ABSTRACT:

Introduction

Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored.

Methods

We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (N = 225).

Results

We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-relat

SUBMITTER: Yadav Y 

PROVIDER: S-EPMC10244515 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature