The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.

ABSTRACT:

Background

Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. We examined if poor sleep contributes as a causal risk factor to respiratory infections.

Methods

We used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.

Findings

Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased

SUBMITTER: Jones SE 

PROVIDER: S-EPMC10248098 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature