Analysis of Antibiotic Exposure and Development of Acute Graft-vs-Host Disease Following Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT:

Importance

Certain antibiotic exposures have been associated with increased rates of acute graft-vs-host disease (aGVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). Since antibiotic exposure can both affect and be affected by infections, analyzing time-dependent exposure in the presence of multiple potential confounders, including prior antibiotic exposures, poses specific analytical challenges, necessitating both a large sample size and unique approaches.

Objective

To identify antibiotics and antibiotic exposure timeframes associated with subsequent aGVHD.

Design, setting, and participants

This cohort study assessed allo-HCT at a single center from 2010 to 2021. Participants included all patients aged at least 18 years who underwent their first T-

SUBMITTER: Rashidi A 

PROVIDER: S-EPMC10248746 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature