Second Allogeneic Hematopoietic Cell Transplantation Following Graft Failure in Children.

ABSTRACT:

Background

Graft failure (GF) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT). Secondary transplantation has been recognized as a potential curative intervention.

Methods

This study aimed to investigate the characteristics and outcomes of salvage transplantation by analyzing the patients who underwent a second HCT for GF following the initial allo-HCT between 1998 and 2020.

Results

Overall, 23 recipients were identified, including 14 and 9 individuals with primary and secondary GF, respectively. Nine recipients underwent a second transplant from the same donor. Familial mismatched donors predominated in the second HCT (86.9%), with reduced-intensity conditioning as the prevailing approach (60.9%). Neutrophil engraftment occurred in

SUBMITTER: Yi ES 

PROVIDER: S-EPMC11913628 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature