Nutrigenetic Interaction Between Apolipoprotein C3 Polymorphism and Fat Intake in People with Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background

Recent genome-wide association studies have revealed that nonalcoholic fatty liver disease (NAFLD) is correlated with genetic polymorphisms. However, the effects of genetic variation on nutritional metabolism and NAFLD are complex and further studies are still needed.

Objectives

This study aimed to assess the nutritional characteristics interacting with the correlation between genetic predisposition and NAFLD.

Methods

We assessed the 2013-2017 health examination data of 1191 adults aged ≥40 y living in Shika town, Ishikawa Prefecture, Japan. Adults with moderate or heavy alcohol consumption and hepatitis were excluded, and 464 participants who underwent genetic analyses were included in the study. Abdominal echography was performed to diagnose fatty liver c

SUBMITTER: Yamamoto R 

PROVIDER: S-EPMC10257212 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature