Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
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ABSTRACT:
SUBMITTER: Alam MM
PROVIDER: S-EPMC10258816 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function.
Alam Md Masud MM Yang De Li Xiao-Qing XQ Liu Jia J Back Timothy Carrel TC Trivett Anna A Karim Baktiar B Barbut Denise D Zasloff Michael M Oppenheim Joost J JJ
Cell reports 20220101 2
Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown. Recent studies demonstrate that αS is induced by noroviral infection in the enteric nervous system of children and protects mice against lethal neurotropic viral infection. Additionally, αS is a potent chemotactic activator of phagocytes. In this report, using both wild-type and αS knockout mice, we show that αS is a critical mediator of ...[more]
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