Association of nitric oxide synthase gene polymorphism with asthma: A systematic review and meta-analysis.

ABSTRACT:

Introduction

This study examines the associations between asthma and nitric oxide (NO) synthase (NOS) gene polymorphisms.

Methods

After a systematic literature search in electronic databases, studies were selected based on eligibility criteria. Data were extracted from research articles and were synthesized and tabulated. Where a particular polymorphism data were reported by multiple studies, meta-analyses of odds ratios were performed, or odds ratios reported by individual studies were pooled.

Results

Twenty studies (4450 asthma patients and 5306 non-asthmatic individuals) were identified. Many studies did not find any association between CCTTT repeat polymorphism in NOS2 gene and asthma. However, a study reported that pretreatment mean exhaled NO levels in asthmatic

SUBMITTER: Fan Z 

PROVIDER: S-EPMC10265172 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature