Lactobacillus acidophilus and propionate attenuate Sjogren's syndrome by modulating the STIM1-STING signaling pathway.

ABSTRACT:

Background

Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on the development and progression of SS in mouse model.

Methods

We compared the gut microbiomes of young and old mice. We administered L. acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro.

Results

Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L. acidophilu

SUBMITTER: Woo JS 

PROVIDER: S-EPMC10265917 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature