Altered anti-viral immune responses in monocytes in overweight heavy drinkers.
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ABSTRACT:
SUBMITTER: Kim A
PROVIDER: S-EPMC10268809 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Publications
Altered anti-viral immune responses in monocytes in overweight heavy drinkers.
Kim Adam A Ortega-Ribera Martí M McMullen Megan R MR Bellar Annette A Taiwo Moyinoluwa M Pathak Vai V Streem David D Dasarathy Jaividhya J Welch Nicole N Dasarathy Srinivasan S Vachharajani Vidula V Nagy Laura E LE
iScience 20230615 7
Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular mechanisms are unexplored. Single-cell RNA-sequencing (scRNA-seq) was performed on peripheral blood mononuclear cells from lean or overweight HD and healthy controls (HC) after challenge with a dsRNA homopolymer (PolyI:C) to mimic a viral infection and/or with ...[more]
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