Dronedarone versus sotalol in patients with atrial fibrillation: A systematic literature review and network meta-analysis.

ABSTRACT:

Background

There are limited comparative data on safety and efficacy within commonly used Vaughan-Williams (VW) class III antiarrhythmic drugs (AADs) for maintenance of sinus rhythm in adults with atrial fibrillation (AF).

Hypothesis

We hypothesized that dronedarone and sotalol, two commonly prescribed VW class III AADs with class II properties, have different safety and efficacy effects in patients with nonpermanent AF.

Methods

A systematic literature review was conducted searching MEDLINE®, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to June 15, 2021 (NCT05279833). Clinical trials and observational studies that evaluated safety and efficacy of dronedarone or sotalol in adults with AF were included. Bayesian random-effects network meta-ana

SUBMITTER: Singh JP 

PROVIDER: S-EPMC10270269 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature