BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.

ABSTRACT: During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules.^1,2 Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting complex/cyclosome (APC/C) activator CDC-20.^3,4,5 Kinetochores either incorporate CDC-20 into checkpoint complexes that inhibit the APC/C or dephosphorylate CDC-20, which allows it to interact with and activate the APC/C.^4,6 The importance of these two CDC-20 fates likely depends on the biological context. In human somatic cells, the major mechanism controlling mitotic progression is the spindle checkpoint. By contrast, progression th

SUBMITTER: Houston J 

PROVIDER: S-EPMC10270731 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature