The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer-novel use of a large administrative database.

ABSTRACT:

Background

Screening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening. We evaluated this association using a large administrative database.

Methods

Patients were identified using claims data from the OptumLabs® Data Warehouse. Adult patients with NoD diagnosis were matched 1:3 with patients without NoD using age, sex and chronic obstructive pulmonary disease (COPD) status. The event of PDAC diagnosis was compared between cohorts using the Kaplan-Meier method. Factors associated with PDAC diagnosis were evaluated with Cox's proportional hazards modeling.

Results

We identified 640 421 patients with NoD

SUBMITTER: White MJ 

PROVIDER: S-EPMC10273390 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature