A positive feedback circuit between RN7SK snRNA and m⁶A readers is essential for tumorigenesis.

ABSTRACT: N⁶-Methyladenosine (m⁶A) RNA modification, methylation at the N6 position of adenosine, plays critical roles in tumorigenesis. m⁶A readers recognize m⁶A modifications and thus act as key executors for the biological consequences of RNA methylation. However, knowledge about the regulatory mechanism(s) of m⁶A readers is extremely limited. In this study, RN7SK was identified as a small nuclear RNA that interacts with m⁶A readers. m⁶A readers recognized and facilitated secondary structure formation of m⁶A-modified RN7SK, which in turn prevented m⁶A reader mRNA degradation from exonucleases. Thus, a positive feedback circuit between RN7SK and m⁶A readers is established in tumor cells. F

SUBMITTER: Xu X 

PROVIDER: S-EPMC10277899 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature