LncRNA landscape and associated ceRNA network in placental villus of unexplained recurrent spontaneous abortion.

ABSTRACT:

Background

Unexplained recurrent spontaneous abortion (URSA) is one of the most challenging conditions frustrates women of childbearing age profoundly. The gene expression patterns and biological characteristics of placental villus in patients with URSA remain largely unknown. The aim of our study was to identify potential lncRNAs as well as their action mechanisms in URSA.

Method

The ceRNA microarray was used to identify the mRNA and lncRNA expression profiles of URSA patients and normal pregnancy. Functional enrichment analyses for differentially expressed mRNAs in URSA were performed. Protein-protein interaction analysis of differentially expressed mRNAs was performed to identify hub genes and key modules. Subsequently, the co-dysregulated ceRNA network of URSA was establ

SUBMITTER: Tang M 

PROVIDER: S-EPMC10280933 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature