Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients.

ABSTRACT:

Background

Alternatives to the Friedewald low-density lipoprotein cholesterol (LDL-C) equation have been proposed.

Objective

To compare the accuracy of available LDL-C equations with ultracentrifugation measurement.

Methods

We used the second harvest of the Very Large Database of Lipids (VLDbL), which is a population-representative convenience sample of adult and pediatric patients (N = 5,051,467) with clinical lipid measurements obtained via the vertical auto profile (VAP) ultracentrifugation method between October 1, 2015 and June 30, 2019. We performed a systematic literature review to identify available LDL-C equations and compared their accuracy according to guideline-based classification. We also compared the equations by their median error versus ultracentrifug

SUBMITTER: Samuel C 

PROVIDER: S-EPMC10289049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature