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Schisandra chinensis-derived gomisin C suppreses lipid accumulation by JAK2-STAT signaling in adipocyte.

ABSTRACT: Gomisin C is a lignan isolated from the fruit of Schisandra chinensis. The current study aimed to investigate the effect of gomisin C on lipid accumulation in adipocytes and its underlying mechanism. Gomisin C effectively inhibited lipid accumulation by downregulating adipogenic factors such as PPARγ and C/EBPα. Gomisin C-mediated suppression of lipid accumulation occurred in the early adipogenic stage; C/EBPβ was downregulated by 55%, while KLF2 was upregulated by 1.5-fold. Gomisin C significantly reduced the production of reactive oxygen species but upregulated antioxidant enzymes, including catalase, SOD1, and Gpx at the mRNA level. Gomisin C regulated NRF2-KEAP1 pathway by increasing NRF2 and decreasing KEAP1, in protein abundance. Furthermore, gomisin C suppressed the JAK2-STAT signaling pathway by decreasing phosphorylation. Taken together, gomisin C reduced early adipogenesis and ROS production by inhibiting the JAK2-STAT signaling pathway but activating the NRF2-KEAP1 signaling pathway.

Supplementary information

The online version contains supplementary material available at 10.1007/s10068-023-01263-8.

SUBMITTER: You YL

PROVIDER: S-EPMC10290005 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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S<i>chisandra chinensis</i>-derived gomisin C suppreses lipid accumulation by JAK2-STAT signaling in adipocyte.

You Ye-Lim YL Lee Ji-Yeon JY Choi Hyeon-Son HS

Food science and biotechnology 20230203 9

Gomisin C is a lignan isolated from the fruit of S<i>chisandra chinensis</i>. The current study aimed to investigate the effect of gomisin C on lipid accumulation in adipocytes and its underlying mechanism. Gomisin C effectively inhibited lipid accumulation by downregulating adipogenic factors such as PPARγ and C/EBPα. Gomisin C-mediated suppression of lipid accumulation occurred in the early adipogenic stage; C/EBPβ was downregulated by 55%, while KLF2 was upregulated by 1.5-fold. Gomisin C sig ...[more]

PMID: 37362811

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