δ-C-H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor.

ABSTRACT: Nitrogen-centered radicals are versatile synthetic intermediates with the ability to undergo diverse reactions such as hydrogen atom transfer (HAT), β-scission, and addition across unsaturated systems. A long-standing impediment to the wider adoption of these intermediates in synthesis has been the difficulty of their generation. Herein we disclose a new hydrazonyl carboxylic acid precursor to nitrogen-centered radicals and its application toward remote C-H fluorination and chlorination reactions of sulfonyl-protected alkyl amines via 1,5-HAT.

SUBMITTER: Herron AN 

PROVIDER: S-EPMC10292861 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature