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Synuclein Proteins in Cancer Development and Progression.

ABSTRACT: Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated with severe human diseases. Although the physiological function of these proteins is still elusive, their relationship with neurodegeneration and cancer has been clearly described over the years. In this review, we summarize data connecting synucleins and cancer, going from the structural description of these molecules to their involvement in tumor-related processes, and discuss the putative use of these proteins as cancer molecular biomarkers.

SUBMITTER: Zanotti LC

PROVIDER: S-EPMC10296229 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Synuclein Proteins in Cancer Development and Progression.

Zanotti Lucía C LC Malizia Florencia F Cesatti Laluce Nahuel N Avila Aylén A Mamberto Macarena M Anselmino Luciano E LE Menacho-Márquez Mauricio M

Biomolecules 20230612 6

Synucleins are a family of small, soluble proteins mainly expressed in neural tissue and in certain tumors. Since their discovery, tens of thousands of scientific reports have been published about this family of proteins as they are associated with severe human diseases. Although the physiological function of these proteins is still elusive, their relationship with neurodegeneration and cancer has been clearly described over the years. In this review, we summarize data connecting synucleins and ...[more]

PMID: 37371560

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