Unknown

Dataset Information

0

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.

ABSTRACT: The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.

SUBMITTER: Aksenov AV 

PROVIDER: S-EPMC10299564 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams.

Aksenov Alexander V AV   Aksenov Dmitrii A DA   Kurenkov Igor A IA   Leontiev Alexander V AV   Aksenov Nicolai A NA  

International journal of molecular sciences 20230616 12

The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medi  ...[more]

Similar Datasets

Unknown An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine.
| S-EPMC3071593 | biostudies-literature
Unknown Synthesis of α-Substituted β,γ-Unsaturated Cyclobutanecarboxamides via Palladium-Catalyzed Aminocarbonylation of Vinylcyclobutanols.
| S-EPMC12538587 | biostudies-literature
Unknown Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters.
| S-EPMC2628291 | biostudies-literature
Unknown Stereoselective Syntheses of α,β-Unsaturated γ-Amino Esters Through Phosphine-Catalyzed γ-Umpolung Additions of Sulfonamides to γ-Substituted Allenoates.
| S-EPMC4450090 | biostudies-literature
Unknown Diastereospecific Synthesis of Vicinally Substituted 2-Oxazolidinones via Oxidative Rearrangement of α,β-Unsaturated γ-Lactams.
| S-EPMC11744868 | biostudies-literature
Unknown A new and convenient synthetic way to 2-substituted thieno[2,3-b]indoles.
| S-EPMC4505097 | biostudies-literature
Unknown Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.
| S-EPMC3733989 | biostudies-literature
Unknown Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers.
| S-EPMC7775104 | biostudies-literature
Unknown Enantioselective [3 + 2] annulation of α-substituted allenoates with β,γ-unsaturated N-sulfonylimines catalyzed by a bifunctional dipeptide phosphine.
| S-EPMC4778533 | biostudies-literature
Unknown Efficient 1,4-addition of alpha-substituted fluoro(phenylsulfonyl)methane derivatives to alpha,beta-unsaturated compounds.
| S-EPMC2486456 | biostudies-literature