LINC01117 inhibits invasion and migration of lung adenocarcinoma through influencing EMT process.

ABSTRACT:

Background

Studying the mechanism of action of LncRNAs in lung adenocarcinoma (LUAD) is of great importance for an in-depth understanding of the molecular mechanism of lung adeno carcinogenesis and development.

Objective

The aim is to identify a long non-coding RNA LINC01117 that is specifically and highly expressed in LUAD cells and to investigate its biological functions and molecular mechanisms in LUAD cells, providing a new potential target for targeting LUAD therapy.

Methods

This study used publicly available data downloaded from The Cancer Genome Atlas (TCGA) database. Construction of siRNA and overexpression plasmid-packed lentiviral constructs were used to knock down and increase the expression of LINC01117 in LUAD cells. The effect of LINC01117 on LUAD cell m

SUBMITTER: Liu L 

PROVIDER: S-EPMC10310029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature