Effect of ultrafiltration on cerebral small-vessel disease and related outcomes in hemodialysis.

ABSTRACT:

Background

Increasing evidence suggests a high prevalence of cerebral small-vessel disease (CSVD) in hemodialysis patients. Variable ultrafiltration during hemodialysis may contribute to brain lesions by inducing hemodynamic instability. We aimed to investigate the effect of ultrafiltration on CSVD and relative outcome in this population.

Methods

In a prospective cohort of maintenance hemodialysis adults, three features of CSVD including cerebral microbleed (CMB), lacunae and white matter hyperintensity (WMH) were measured by brain magnetic resonance imaging. Ultrafiltration parameters included the difference between annual average ultrafiltration volume (UV, kg) and 3%-6% of dry weight (kg), respectively, and the percentage of UV to dry weight (UV/W). The effect of ultrafil

SUBMITTER: Shi L 

PROVIDER: S-EPMC10310522 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature