Human ovarian gross morphology and subanatomy across puberty: insights from tissue donated during fertility preservation.

ABSTRACT:

Objective

To study ovarian gross morphologic and subanatomic features across pubertal development.

Design

Prospective cohort study.

Setting

An academic medical center with specimens collected from 2018-2022.

Patients

Tissue was obtained from prepubertal and postpubertal participants (0.19-22.96 years) undergoing ovarian tissue cryopreservation before treatment that put them at a significantly or high increased risk of developing premature ovarian insufficiency. Most participants (64%) had not received chemotherapy at tissue collection.

Interventions

None.

Main outcome measures

Ovaries procured for fertility preservation were weighed and measured. Ovarian tissue fragments released during processing, biopsies used for pathology, and hormone panels w

SUBMITTER: Tsui EL 

PROVIDER: S-EPMC10310944 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature