Heterogeneous treatment effects of intensive glycemic control on kidney microvascular outcomes in ACCORD.

ABSTRACT:

Objective

Clear criteria to individualize glycemic targets are lacking. In this post-hoc analysis of the Action to Control Cardiovascular Risk in Diabetes trial (ACCORD), we evaluate whether the kidney failure risk equation (KFRE) can identify patients who disproportionately benefit from intensive glycemic control on kidney microvascular outcomes.

Research design and methods

We divided the ACCORD trial population in quartiles based on 5-year kidney failure risk using the KFRE. We estimated conditional treatment effects within each quartile and compared them to the average treatment effect in the trial. The treatment effects of interest were the 7-year restricted-mean-survival-time (RMST) differences between intensive and standard glycemic control arms on (1) time-to-first de

SUBMITTER: Charu V 

PROVIDER: S-EPMC10312895 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature