A Systematic Review of LINE-1 Methylation Profile in Psychiatric Disorders.

ABSTRACT:

Introduction

Long interspersed nuclear elements (LINEs) are endogenous retrotransposable elements. A few studies have linked the methylation pattern of LINE-1 to different mental disorders (e.g., post-traumatic stress disorder [PTSD], autism spectrum disorder [ASD], panic disorder [PD]). We sought to unify the existing knowledge in the field and provide a better understanding of the association between mental disorders and LINE-1 methylation.

Methods

A systematic review was executed with 12 eligible articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

For psychotic disorders, PTSD, ASD, and PD, lower LINE-1 methylation levels were detected, whereas for mood disorders, the findings are controversial.

SUBMITTER: Alves VRG 

PROVIDER: S-EPMC10315007 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature