Age and sex differentially shape brain networks in Parkinson's disease.

ABSTRACT:

Aims

Age and sex are important individual factors modifying the clinical symptoms of patients with Parkinson's disease (PD). Our goal is to evaluate the effects of age and sex on brain networks and clinical manifestations of PD patients.

Methods

Parkinson's disease participants (n = 198) receiving functional magnetic resonance imaging from Parkinson's Progression Markers Initiative database were investigated. Participants were classified into lower quartile group (age rank: 0%~25%), interquartile group (age rank: 26%~75%), and upper quartile group (age rank: 76%~100%) according to their age quartiles to examine how age shapes brain network topology. The differences of brain network topological properties between male and female participants were also investigated.

Results

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10324368 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature