Pan-cancer mutational signature analysis of 111,711 targeted sequenced tumors using SATS.
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ABSTRACT:
SUBMITTER: Lee D
PROVIDER: S-EPMC10327246 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
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Pan-cancer mutational signature analysis of 111,711 targeted sequenced tumors using SATS.
Lee Donghyuk D Hua Min M Wang Difei D Song Lei L Zhang Tongwu T Hua Xing X Yu Kai K Yang Xiaohong R XR Chanock Stephen J SJ Shi Jianxin J Landi Maria Teresa MT Zhu Bin B
medRxiv : the preprint server for health sciences 20240731
Tumor mutational signatures are informative for cancer diagnosis and treatment. However, targeted sequencing, commonly used in clinical settings, lacks specialized analytical tools and a dedicated catalogue of mutational signatures. Here, we introduce SATS, a scalable mutational signature analyzer for targeted sequencing data. SATS leverages tumor mutational burdens to identify and quantify signatures in individual tumors, overcoming the challenges of sparse mutations and variable gene panels. V ...[more]
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