Analysis of urine differential proteins in patients with allergic rhinitis.

ABSTRACT:

Background

Allergic rhinitis (AR) is one of the most common clinical allergic diseases. Early diagnosis and medical intervention will benefit patients with allergic rhinitis. In this study, we focused on changes in urine proteomics in AR patients to investigate their potential clinical utility in AR diagnosis and evaluation.

Material and methods

TMT-labeled mass spectrometry-based proteomics was carried out to identify differentially expressed proteins (DEPs) in urine between allergic rhinitis patients and normal control groups. The molecular biological role of DEPs was investigated by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and protein-protein interaction (PPI) network analysis.

Results

Enrichment analysis showed that the differen

SUBMITTER: Liu N 

PROVIDER: S-EPMC10329111 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature