Fasting and Post-Load Glucose and Non-Esterified Fatty Acids and Risk of Heart Failure and Its Subtypes in Older Adults.

ABSTRACT:

Background

Glucose and non-esterified fatty acids (NEFA) are myocardial fuels whose fasting and post-prandial levels are under different homeostatic regulation. The relationships of fasting and post-load glucose and NEFA with incident heart failure (HF) remain incompletely defined.

Methods

Serum glucose and NEFA were measured during fasting and 2 hours post-oral glucose tolerance test, performed in Cardiovascular Health Study participants not receiving hypoglycemic medication. Participants with prevalent HF or lacking relevant data were excluded. Outcomes were incident HF (primary), and HF with preserved (HFpEF) and reduced (HFrEF) ejection fraction (secondary).

Results

Among 2 238 participants (age 78 ± 4) with a median follow-up of 9.9 years, there were 737 HF event

SUBMITTER: Oesterle A 

PROVIDER: S-EPMC10329227 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature