Role of Circulating Exosomal miRNA-3976 in Early Diabetic Retinopathy.

ABSTRACT:

Background

Diabetic retinopathy (DR) remains as the most frequent complication of diabetes, and is the major cause of vision loss for middle-aged to elderly people. With longer life expectancies for people with diabetes, there is a significant rise in diabetic retinopathy worldwide. The treatment of DR is limited; and therefore, our study aimed to investigate the possibilities of circulating exosomal miRNAs in the early screening and prevention of DR; and to explore the function of the exosomal miRNAs in DR.

Materials and methods

Eighteen participants were recruited and divided into two groups: the diabetes mellitus (DM) group and the DR group. We analyzed the expression profile of exosomal miRNAs derived from serum using RNA sequencing. Additionally, we conducted co-culture

SUBMITTER: Yang S 

PROVIDER: S-EPMC10329447 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature