Dataset Information

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by ¹⁸F-FDG PET/CT in early-stage non-small cell lung cancer.

ABSTRACT:

Background

The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic NSCLC indicate that ctDNA levels are associated with tumor metabolic activity as measured by ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET/CT). This study investigated this association in NSCLC patients considered for potentially curative treatment and explored whether the two methods provide independent prognostic information.

Method

Patients with stage I-III NSCLC who had routinely undergone an ¹⁸F-FDG PET/CT scan and exploratory ctDNA analyses were included. Tumor glucose uptake was measured by maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) from the ¹⁸F-FDG PET/CT scans. ctDNA detectability and quantity, using variant allele frequency, were estimated by tumor-informed ctDNA analyses.

Results

In total, 63 patients (median age 70 years, 60% women, and 90% adenocarcinoma) were included. The tumor glucose uptake (SUVmax, MTV, and TLG) was significantly higher in patients with detectable ctDNA (n = 19, p < 0.001). The ctDNA quantity correlated with MTV (Spearman's ρ = 0.53, p = 0.021) and TLG (Spearman's ρ = 0.56, p = 0.013) but not with SUVmax (Spearman's ρ = 0.034, p = 0.15). ctDNA detection was associated with shorter OS independent of MTV (HR: 2.70, 95% CI: 1.07-6.82, p = 0.035) and TLG (HR: 2.63, 95% CI: 1.06-6.51, p = 0.036). Patients with high tumor glucose uptake and detectable ctDNA had shorter overall survival and progression-free survival than those without detectable ctDNA, though these associations were not statistically significant (p > 0.05).

Conclusion

There was a positive correlation between plasma ctDNA quantity and MTV and TLG in early-stage NSCLC patients. Despite the correlation, the results indicated that ctDNA detection was a negative prognostic factor independent of MTV and TLG.

SUBMITTER: Ottestad AL

PROVIDER: S-EPMC10334612 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Associations between detectable circulating tumor DNA and tumor glucose uptake measured by <sup>18</sup>F-FDG PET/CT in early-stage non-small cell lung cancer.

Ottestad Anine Larsen AL Johansen Håkon H Halvorsen Tarje Onsøien TO Dai Hong Yan HY Wahl Sissel Gyrid Freim SGF Emdal Elisabeth Fritzke EF Grønberg Bjørn Henning BH

BMC cancer 20230711 1

<h4>Background</h4>The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic NSCLC indicate that ctDNA levels are associated with tumor metabolic activity as measured by <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET/CT). This study investigated this association in NSCLC patients considered for potentially c ...[more]

PMID: 37434111

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Dataset Information

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by ¹⁸F-FDG PET/CT in early-stage non-small cell lung cancer.

Background

Method

Results

Conclusion

Publications

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by <sup>18</sup>F-FDG PET/CT in early-stage non-small cell lung cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer.

Background

Method

Results

Conclusion

Publications

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by <sup>18</sup>F-FDG PET/CT in early-stage non-small cell lung cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Associations between detectable circulating tumor DNA and tumor glucose uptake measured by ¹⁸F-FDG PET/CT in early-stage non-small cell lung cancer.