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Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors.

ABSTRACT: Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it can be tumor suppressive at early stages but tumor promotional in established disease. This review highlights the controversial roles of autophagy in endocrine-dependent tumors regarding cancer initiation, tumorigenesis, metastasis, and treatment response. We summarize clinical trial results thus far and highlight the need for additional mechanistic, preclinical, and clinical studies in endocrine-dependent tumors, particularly in breast cancer and prostate cancer.

SUBMITTER: Komarla A

PROVIDER: S-EPMC10335171 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors.

Komarla Anvita A Dufresne Suzanne S Towers Christina G CG

Endocrine reviews 20230701 4

Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it can be tumor suppressive at early stages but tumor promotional in established disease. This review highlights the controversial roles of autophagy in endocrine-dependent tumors regarding cancer initiation, tumorigenesis, metastasis, and treatment response. We ...[more]

PMID: 36631217

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